How is hemophilia caused?
Hemophilia is caused by an X-linked recessive defect (inherited or spontaneous mutation) or antibody production against clotting factors.
List the 3 types of hemophilia.
Hemophilia A (factor VIII deficiency): ∼ 80% of cases
Hemophilia B (factor IX deficiency): ∼ 20% of cases
Hemophilia C (factor XI deficiency): very rare (increased frequency in the Ashkenazi Jewish population); caused by an autosomal recessive defect
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