Endosymbiont theory
Mitochondria - structure and bioenergetics
Heteroplasmy
Mitochondria - features of mtDNA
Mitochondrial decline - a hallmark of aging
The free radical theory of aging
concentartion of free radicals increases with metabolic activity
respiratory enzymes as source of radicals
free radicals react near where they are produced (with mtDNA?)
result could be mutations and cancer
chemicals (as cysteine, a ROS scavenger) slow down aging and aging-related disease
reactive oxygen species
POLG mutator mouse model
POLG = Polymerase for mtDNA replication with exonuclease (“proofreading”) activity
MnSod2 mutants (manganese superoxide dismutase 2)
Questions regarding the free radical theory of aging:
Does global DNA repair-deficiency accelerate ageing?
Do mtDNA mutations lead to accelerated ageing?
Is there a causal connection between ROS and (accelerated) ageing?
Does the mtDNA mutation type matter?
Mitochondrial communication
Mitochondrial proteolysis - overview
Proteostasis in mitochondria
UPRmt and lifespan
Last changed13 days ago
