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Name the category.
Cytotoxic agents
Name the main drug.
Doxorubicin
What is the drug group of doxorubicin?
Anthracyclines
Describe the mechanism of action
Inhibition of topoisomerase II → ↑ DNA degradation (dsDNA breaks) and ↓ DNA replication
Formation of free radicals → breakage of DNA strands
DNA intercalation → breakage of DNA strands and ↓ DNA replication
List indications.
Breast cancer (doxorubicin)
Metastatic solid tumors (doxorubicin)
Leukemias (daunorubicin, idarubicin)
Lymphomas (doxorubicin)
Kaposi sarcoma (doxorubicin)
Osteosarcoma
List side effects.
Cardiotoxicity: dilated cardiomyopathy with systolic CHF
Myelosuppression
Alopecia
Extravasation
Infertility
Urine discoloration
Last changed2 years ago