Otic Anti-infectives

Otic agents

• Betametasone ear drops

• Gentamicin ear drops

• Gentamicin and hydrocortisone ear drops

• Betametasone ear drops

• Weil EDU einfach nur behindert ist

• Topical treatment of superficial bacterial infections of the eye caused by susceptible bacteria

  • Mild, acute bacterial conjunctivitis often resolves spontaneously without anti-infective treatment. Although topical ophthalmic anti-infectives may shorten time to resolution and reduce severity and risk of complications, avoid indiscriminate use of topical anti-infectives

Fixed-combination ophthalmic preparations containing gentamicin and a corticosteroid (i.e., prednisolone): Topical treatment of corticosteroid-responsive ocular conditions when a corticosteroid indicated and superficial bacterial ocular infection or risk of such infection exists

• Usually bactericidal

• Mechanism of action not fully elucidated; appears to inhibit protein synthesis in susceptible bacteria by irreversibly binding to 30S ribosomal subunits

• Spectrum of activity of gentamicin includes many aerobic gram-negative and some aerobic gram-positive bacteria. Inactive against fungi, viruses, and most anaerobic bacteria

• Gram-positive bacteria: Active in vitro against Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae, and S. pyogenes.

• Gram-negative bacteria: Active in vitro against Haemophilus influenzae, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, Serratia marcescens, and Pseudomonas aeruginosa

in both gram-negative and gram-positive bacteria

Hypersensitivity to gentamicin or any ingredient in the formulation

• known or suspected hypersensitivity to gentamicin, prednisolone or other corticosteroids, or any ingredient in the formulation

• patients with viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella; with mycobacterial infections of the eye; or fungal diseases of ocular structures

• Ocular burning and irritation

• nonspecific conjunctivitis

• conjunctival epithelial defects

• conjunctival hyperemia