Name the category.
Antiemetics
Name one drug.
Ondansetron.
To which antiemetic class does ondansetron belong to?
Serotonin receptor antagonists
(5-HT3 antagonists)
Describe the mechanism of action.
5-HT3 antagonist
Strong central antiemetic effect at the area postrema
Peripheral antiemetic effect via inhibition of the vagus nerve
Describe the clinical use.
Ondansetron is commonly used for generalized nausea.
Chemotherapy-induced vomiting, radiation-induced vomiting, and postoperative nausea and vomiting (PONV)
List common side effects.
Headaches
Constipation or diarrhea
QT interval prolongation (torsades de pointes)
Increase in liver enzymes
Serotonin syndrome
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