Name the category.
Inflammatory Bowel Disease Agents
Name the main drug.
Infliximab
Describe the drug type of infliximab.
Anti-TNF-α antibodies —> Chimeric anti-TNF-α monoclonal antibody
What is the target of infliximab?
TNF-α inhibition
Describe the indication of infliximab.
Refractory-therapy for chronic inflammatory systemic diseases
Rheumatoid arthritis
Ankylosing spondylitis
Psoriasis, psoriatic arthritis
Crohn disease, ulcerative colitis (except for etanercept, which is not effective in the treatment of inflammatory bowel disease)
List adverse effects of infliximab.
Severe infections
Reactivation of prior infections (e.g., latent TB): Patients should be screened for HBV, HCV, EBV, CMV, VZV, and M. tuberculosis prior to treatment.
Drug-induced lupus
List contraindications.
Doses >5 mg/kg in patients with moderate or severe heart failure.
Prior severe hypersensitivity reaction to infliximab products; known hypersensitivity to murine proteins or any ingredient in the formulations.
Last changed2 years ago