rheumatoid arthritis

Chronic inflammatory disorder affecting mainly the [small joint] of the “ hand “

UNKNOWN

ولكن ممكن

EBV (epstein barr virus) may bind to TCR (t cell receptor) on t cells and triggers autoimmunity against antigens

T cell —> B cell —> Ab production IgM against the Fc receptor of Autologous IgG

ال rheumatoid factor

الي هو اساس المشكله عباره عن

IgM

مكون ضد ال

IgG

تبع الجسم "autologous"

تحديدا ضد جزء ال

fc part

[ف هو خليط ال IgM ماسك مع ال IgG]

1- Boutonniere deformity 2-swollen joint capsule 3- pannus formation (بدخل بين ال bone وال cartilage وبعمل damage لل cartilage ) 4- bone erosion 5- rheumatoid nodules