Etiology

Atherosclerosis

• Atherosclerosis in the aorta and peripheral arteries → insufficient tissue perfusion → PAD

• Often coexists with coronary artery disease (CAD), stroke, atrial fibrillation, and renal disease

• See risk factors for atherosclerosis

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Risk factors for PAD: The following patient groups are at increased risk of PAD.

• Age ≥ 65 years

• Age 50–64 years with risk factors for atherosclerosis (e.g., smoking) or a family history of PAD

• Age ≤ 50 years of age with diabetes plus additional risk factors for atherosclerosis.