Cartilage repair

• Connective tissue that covers and protects the endsof bones at a joint

• Serves as a dampening friction bearing

• Smooth flexible strong

• Limited self repair ability

• Hyaline

• Fibrous

• Elastic

• low friction

• wear-resistent

• designed to bear and dstribute weight

• Example: Femoral joint, nose

• Flexible

• Bounce back to original shape

• Example: Ear

• Very strong

• inflexible

• Designed to hold parts of your body in place and absorb impacts

• Example: Meniscus

• Collagen: gives form and strength

• Proteogylcans: provide flexibility and cushioning qualities

• elastin fibers: stretchable to many times their length and snap back without energy loss

• Repair

• Reconstruction

• Salvage

  
  

• via injections of hyaluronic acids to stabilze ECM or platetet rich plasma

• weak evidence of treatment success

1. Debridement

2. Ostheochondral autograft transplantation

3. Microfracturing

4. Matrix-augmented microfracturing

5. Autologus chondrocyte implantation (ACI, Charli)

• Creation of microfractures during surgery

• Stimualtion of chondrocyte release which create the ECM

• No zonal organzisation, little cell supply and cell-density

F = k*(x-x0)