Rhabdoviridae

Group V RNA -

• (-)RNP serves as template for both transcription and genome replication

• Level of N protein determines which step occurs

Rhabdoviridae Class III

 humans, other vertebrates, invertebrates, and plants. 

• causative agent of rabies

• Tollwut

• Rabies is a viral disease that causes encephalitis in humans and other mammals

• dog transmitted rabies

• vaccine

• Rabies as a monosynaptic tracer

  • Single network monitoring

  • Network activity monitoring

  • Manipulation of neuronal activity of a network

• causative agent of vesicular stomatitis

interferoon response

Autophagy is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components

Autophagy pathway hijacked by rhabdoviruses

• is a form of programmed cell death 

• Intrinsic pathway (trigger: growth factor deprivation & cellular stress)

• - Extrinsic pathway (trigger: recognition of FAS ligand (FASL)

•  inflammatory form of cell death

• pyroptosis acts as “whistle blowers”, resulting in the release of alarmins and other proinflammatory signals into the cellular surroundings,

ISGs inhibiting rhabdoviral replication

•  interferon-stimulated gene

• inhibit secondary transcription

VSV – vesicular stomatitis virus

• The matrix (M) protein of the virus causes many of the cytopathic effectsof VSV, including an inhibition of host gene expression and the induction of cell rounding.