Which cells express MHC I?
All nucleated (zellen mit kern) cells (except red blood cells) → present intracellular antigens to CD8⁺ T cells.
Which cells express MHC II ?
Only professional APCs (dendritic cells, macrophages, B cells).
What kind of antigens does MHC I present?
Intracellular (endogenous) antigens → e.g. viral proteins, tumor proteins.
What kind of antigens does MHC II present?
Extracellular (exogenous) antigens that have been taken up and digested.
Which T-cell subset recognizes MHC I?
CD8⁺ cytotoxic T cells.
Which T-cell subset recognizes MHC II?
CD4⁺ helper T cells.
What happens when a CD8⁺ T cell recognizes its antigen on MHC I?
It kills the infected or transformed cell (cytotoxic function).
What happens when a CD4⁺ T cell recognizes its antigen on MHC II?
It becomes a helper T cell, secretes cytokines, and activates B cells, macrophages, or CD8⁺ T cells.
How do B cells present antigens?
They take up antigen via their BCR, process it, and present fragments on MHC II to CD4⁺ T cells.
Which APC (antigen presenting cells) is best at priming naive T cells?
Dendritic cells.
Which APC is best at killing microbes after activation?
Macrophagen
Which APC is best at producing antibodies after activation?
B cells
What is the progenitor of B cells and where do they develop
CLP (common lymphoid progenitor)
bone marrow
What is the progenitor of T cells and where do they develop?
CLP
Thymus
What is the progenitor of NK cells and where do they develop?
What is the progenitor of ILCs (innate lymphoid cells) and where do they develop?
periphere tissue
What is the progenitor of neutrophile and where do they develop?
CMP (common myeloid progenitors)
bone narrow
what are the two cells of the adaptiv immune system
T and B cells
What is the progenitor of Eosinophile and where do they develop?
CMP
What is the progenitor of Basophile and where do they develop?
What is the progenitor of Monozyten and where do they develop?
What is the progenitor of Makrophagen and where do they develop?
Monozyten
Which cells express MHC I ?
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